Blar i forfatter "Rischmueller, Maureen"

Viser treff 1-2 av 2

    • Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis 

      Graf, S; Lester, Susan; Nossent, Johannes C; Hill, C; Proudman, S. M; Lee, A; Rischmueller, Maureen (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-02-07)
      Introduction: Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether ...

    • Susceptibility for Lupus Nephritis by low copy number of the FCGR3B gene is linked to increased levels of pathogenic autoantibodies 

      Nossent, Johannes C; Becker-Merok, Andrea; Rischmueller, Maureen; Lester, Sue (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (𝑛 = 107). FCGR3B CN was determined by three different qPCR parameter estimations (Ct−, Cy0, and cpD1) and confirmed by the FCGR2C/FCGR2A paralog ratio test. ...